Zuclopenthixol marketed as cisordinol, clopixol or acuphase is a typical antipsychotic neuroleptic drug of the thioxanthene group. These medicines act on nerve pathways in specific areas of the brain and help to correct certain chemical imbalances in the brain that are causing the symptoms of your illness. Among eight women who received 450mg zuclopenthixol daily, an average mp ratio of 0. Zuclopentixol injection this is an easy way to read this word. Zuclopenthixol can sometimes be called a different names like clopixol and zuclopenthixol decanoate. Zuclopenthixol is a thioxanthenebased neuroleptic with therapeutic actions similar to the phenothiazine antipsychotics. Tell your doctor about the allergy and what signs you had. When there is an advance directive for the use of zuclopenthixol acetate. Seventeen outpatients were treated with depot neuroleptics, zuclopenthixol decanoate in viscoleo or fluphenazine decanoate in sesame oil, with dosage intervals of 3 weeks. If you have an allergy to zuclopenthixol or any other part of this drug. Improvement of zuclopenthixol decanoate induced tardive dyskinesia after switching to paliperidone palmitate. The medication is blocking many receptors in the brain, including dopamine receptors, which controls behavior and mood.
Clopixol injection contains the active substance zuclopenthixol. Zuclopenthixol is a mediumacting drug and has an onset of action in 1 hour and a duration of action of about 3 to 4 days. Zuclopenthixol is a generic medicine name and there are several brands available for it. This leaflet was produced in october 2006 what do i need to know about zuclopentixol. As for other neuroleptics, zuclopenthixol is distributed with highest. Zuclopenthixolcisordinol generic is a neuroleptic or antipsychotic compound, prescribed for schizophrenia and other mental health disorders. Major brands of zuclopenthixol are cisordinol, acuphase, and clopixol. Zuclopenthixol was associated with no greater risk of being unchanged or worse compared with risperidone n 98, 1 rct, rr 1. The elimination of zuclopenthixol after single oral dose administration has been shown to be dependent on cyp2d6 activity dahl et al. What zuclopenthixol decanoate looks like and contents of the pack zuclopenthixol decanoate is a clear, yellowish oil in transparent glass ampoules with a red scored dot. Clopixol tablets 2, 10 and 25mg patient information leaflet. Guidelines for the use of zuclopenthixol acetate draft 5final. Fowlers zoo and wild animal medicine, volume 8, 2015.
Po adults acute psychoses 1050 mgday in 23 divided doses initially. A dose of 200 mg2 weeks or 400 mg4 weeks zuclopenthixol decanoate is expected to be equivalent to a daily dose of 25 mg zuclopenthixol as the dihydrochloride. Zuclopenthixol decanoate is available in a carton of 10 ampoules. The other ingredients are potato starch, lactose, microcrystalline cellulose, copolyvidone, glycerol, talc, hydrogenated castor oil, magnesium stearate, methylhydroxypropyl cellulose, macrogol, titanium dioxide e171 and the red. Zuclopentixol this is an easy way to read this word zooclo. Zuclopenthixol brand names cisordinol, clopixol and others, also known as zuclopentixol, is a medication used to treat schizophrenia and other psychoses. The effects of zuclopenthixol on aggressive behavior in patients with intellectual disabilities have previously been investigated seda32, 112, and a secondary parameter analysis of the results of this study has been published 141 r. When there is a documented history that the patient experienced a good clinical effect and good tolerability. Severe laryngeal dystonia in a patient receiving zuclopenthixol acuphase and fluoxetine. Zuclopenthixol as dihydrochloride read all of this leaflet carefully before you start taking this medicine because it contains important information for you. Zuclopenthixol decanoate for schizophrenia and other serious mental illnesses. It is produced and marketed by lundbeck pharmaceutical company. Information about zuclopenthixol decanoate injection. Zuclopenthixol zuclopenthixol is a medication that will help if you have schizophrenia or other psychosis.
Zuclopentixol injection this is an easy way to read this. Christof schaefer, in drugs during pregnancy and lactation second edition, 2007. Clopixol tablets 2, 10 and 25mg patient information. Manufacturer and product licence holder manufactured by h. Each tablet contains 2 mg, 10 mg or 25 mg of zuclopenthixol. Schizophrenia is a condition where a person loses clarity of thought and memory. Zuclopenthixol can be used off label to help people with we have a leaflet which tells you what off label means. Clopixol injection patient information leaflet pil emc. It belongs to a group of medicines known as antipsychotics also called neuroleptics. Most manufacturers advise avoiding the use of two or more drugs that are associated with qt prolongation. Plasma concentrations of the active neuroleptic drugs, zuclopenthixol and fluphenazine, were.
This page was last edited on 10 december 2015, at 00. This medication is a longacting form of zuclopenthixol that is used to treat a certain mentalmood problem chronic schizophrenia. Zuclopenthixol can sometimes be called a different name like clopixol. Some of the brands for zuclopenthixol might be better known than zuclopenthixol itself. Plasma concentrations of the active neuroleptic drugs, zuclopenthixol and fluphenazine, were determined by high performance liquid. A limited number of patients switched from a typical to an atypical antipsychotic or were given exceptionally a typical antipsychotic during hospitalization. During the 4th, 6th, and 8th dosage interval blood samples were drawn in oxalated tubes. It is classed, pharmacologically, as a typical antipsychotic.
This drug is a medicine for this condition as well as some other problems and is a well known antipsychotic drug. Guidelines for the use of zuclopenthixol acetate clopixol acuphase injection introduction in the past, acuphase has often been too widely and possibly inappropriately used, sometimes without full regard being given to the fact that it is a potentially hazardous and toxic preparation with very little published information to support its use. Both esters of zuclopenthixol are dissolved in fractionated coconut oil and when injected i. Search the australian register of therapeutic goods. All structured data from the file and property namespaces is available under the creative commons cc0 license. People allocated zuclopenthixol were prescribed antiparkinsonian medication more frequently compared with those treated with risperidone n 98, 1 rct, rr 1. Zuclopenthixol is a drug that is aimed at treating and curing the disease schizophrenia.
Zuclopenthixol is predicted to decrease the effects of amantadine. Comparative study of the pharmacokinetics of zuclopenthixol. Find information on zuclopenthixol in daviss drug guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. Zuclopentixol this is an easy way to read this word zoo.
Zuclopenthixol cisordinol generic is a neuroleptic or antipsychotic compound, prescribed for schizophrenia and other mental health disorders. Zuclopenthixol memorial sloan kettering cancer center. Jan 25, 2017 the active substance is zuclopenthixol dihydrochloride. Tablets zuclopenthixol 2mg tablets tablets zuclopenthixol 10mg tablets zuclopenthixol dihydrochloride this product is available using any of the above names but will be referred to as clopixol tablets throughout this leaflet. A typical antipsychotic neuroleptic drug of the thioxanthene group. Reduction in selfharming behaviour after zuclopenthixol decanoate article pdf available in progress in neurology and psychiatry 184 july 2014 with 225 reads how we measure reads. Guidelines for the use of zuclopenthixol acetate injection. If the pharmacy thats willing to deliver medicines to your home doesnt have zuclopenthixol in stock, you can ask for one of the branded alternatives for zuclopenthixol. In nursing mothers zuclopenthixol is excreted in small amounts with the breast milk.
Guidelines for the use of zuclopenthixol acetate clopixol. Zuclopenthixol clopixol, clopixol acuphase, clopixol concentrate is a first generation antipsychotic you can find detailed information about this drug in the official patient information leaflet pil, including what its for, how to take it, possible side effects and safety information. Average levels of zuclopenthixol in dogs injected zuclopenthixbl dihydrochloride in aqueous solution n 4 l, zuclopenthixol acetate in oil n 4 2 and zuclopenthixol decanoate. Zuclopenthixol injection for behaviour problems this is an unofficial information leaflet. Initially 2030 mg daily in divided doses, increased if necessary up to 150 mg daily.
Zuclopenthixol decanoate as a very lipophilic substance is slowly released from the oil depot. It is an antagonist at d1 and d2 dopamine receptors. In an attempt to hasten the antipsychotic effect of other prescribed antipsychotics. An intramuscular injection takes 36 hours to produce a maximum serum concentration. Download leaflet view the patient leaflet in pdf format. We have a leaflet which tells you what off label means.
It mainly acts by antagonism of d 1 and d 2 dopamine receptors, though it also has some antihistamine activity. A very bad and sometimes deadly health problem called neuroleptic malignant. This drug is a medicine for this condition as well as some other problems. Both zuclopenthixol and amifampridine prolong the qt interval. Zuclopenthixol clopixol, clopixol acuphase, clopixol concentrate is a first generation antipsychotic you can find detailed information about this drug in the official patient information leaflet pil, including what its for, how to take it. Zuclopenthixol uses, side effects, substitutes, composition. Zuclopenthixol drug information indications, dosage. Dose should be v to lowest dose needed to control symptoms usual range 2040 mgday. Zuclopenthixol is a medication that will help if you have schizophrenia or other psychosis.
It is the cisisomer of clopenthixol sordinol, ciatyl. Files are available under licenses specified on their description page. Zuclopenthixol acetate and zuclopenthixol decanoate are longacting forms of zuclopenthixol that have been made more lipophilic by esterification with acetic and decanoic acid, respectively. This formulation of zuclopenthixol is indicated for the treatment of acute psychoses, mania or exacerbations of chronic psychoses. Zuclopenthixol definition of zuclopenthixol by medical. Maximum concentration was obtained after 4 days in the dogs, then the curve declined very slowly, zuclopenthixol being measurable until 28 days after injection. Zuclopenthixol is excreted mainly with faeces, but also to some degree about 10 % with the urine. The concentration falls by approximately 60% over 3 days so the injection can be repeated after 2 or 3 days if needed. Clopenthixol was introduced in 1961, while zuclopenthixol was introduced in 1978.
1369 827 829 1552 1461 1183 1206 1685 610 675 438 982 1594 912 1305 995 90 21 333 93 1292 938 1107 915 528 612 113 479 1231 826 1272 899 142 228